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KMID : 1037620170040020051
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Pediatric Emergency Medicine Journal
2017 Volume.4 No. 2 p.51 ~ p.57
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High white blood cell count and erythrocyte sedimentation rate are associated with perforated appendicitis in children
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Kim Yoon-Ho
Woo Seon-Hee
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Abstract
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Purpose: To investigate the predictors of perforated appendicitis (PA) in pediatric patients with appendicitis seen in the emergency department.
Methods: We retrospectively reviewed 564 pediatric patients (< 16 years) who visited the emergency department and subsequently had pathologically confirmed appendicitis from 2005 through 2014. Clinical features, inflammatory markers, including the white blood cell (WBC), neutrophil, and lymphocyte counts, neutrophil-to-lymphocyte ratio, C-reactive protein (CRP) concentration, erythrocyte sedimentation rate (ESR), and the Alvarado score were compared between the patients with and without PA regarding their predictability of PA.
Results: Of 564 pediatric patients with appendicitis, 204 (36.2%) had PAs. The patients with PA had longer duration of symptoms and median length of hospital stay, more frequent nausea and vomiting, and higher median WBC and neutrophil counts, neutrophil-to-lymphocyte ratio, ESR, and CRP concentration. Overall, WBC count showed the highest sensitivity of 79.9% and negative predictive value of 82.6%, and CRP concentration had the highest area under the receiver operating characteristic curve of 0.72. Multivariable logistic analysis showed that WBC count > 13.5 × 109/L (odds ratio [OR], 3.27; confidence interval [CI], 1.49-7.18; P = 0.003) and ESR > 15 mm/h (OR, 3.18; 95% CI, 2.13-4.74; P < 0.001) are independent predictors of PA.
Conclusion: WBC count and ESR might be better predictors of PA in pediatric patients with appendicitis in the emergency department than the Alvarado score and CRP concentration.
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KEYWORD
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Blood Sedimentation, Emergencies, Leukocyte Count, Pediatrics, Perforated Appendicitis, Prognosis
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